Effect of caloric restriction with or without physical activity on body composition and epicardial fat in type 2 diabetic patients: A pilot randomized controlled trial

Background and aims There is debate over the independent combined effects of caloric restriction (CR) physical activity (PA) on reduction in fat mass epicardial thickness. We compared impact a similar energy deficit prescription by CR or with PA total mass, thickness, cardiometabolic profile individuals type 2 diabetes. Methods results In this 16-week randomized controlled study, 73 were randomly enrolled to receive: 1) monthly motivational phone call (Control), 2) ?700 kilocalories/day (CR), 3) ?500 program ?200 (CR&PA). Total fat, measured at baseline after 16 weeks. While comparable weight loss occurred both intervention groups (?3.9 ± 3.5 kg [CR], ?5.1 4.7 [CR&PA], ?0.2 2.9 [Control]), changes significantly different between all (?2.4 ?4.5 3.4 +0.1 2.1 [Control]; p < 0.05) as well thickness (?0.4 1.6 mm ?1.4 1.4 +1.1 1.3 0.05). no significant differences trends for parameters improvement groups. Conclusions For loss, combination CR&PA provides greater than alone prescription. These results, however, do not translate into improvements profiles. Clinicaltrials.gov identifier NCT01186952.